Cyclic ADP-ribose (cADPR) is a potent second messenger forcalcium mobilizationthat is synthesized from NAD⁺by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly byRyanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening ofTRPM2 channels^[1][2][3].

Calcium mobilization^[1]
TRPM2 channels^[3]
Endogenous metabolite^[1]

cADPR (20 nM) elicits a large rapid Ca²⁺release in sea urchin eggs homogenates^[1].
cADPR (100 μM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes^[4].
cADPR (100 μM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture^[5].

cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice^[5].

541.30

Solid

C₁₅H₂₁N₅O₁₃P₂

119340-53-3

环ADP核糖；环二磷酸腺苷核酸糖；环状ADP核糖

• Others

Room temperature in continental US; may vary elsewhere.

-80°C

H₂O : 5 mg/mL(9.24 mM;Need ultrasonic and warming)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months。-80℃ 储存时，请在 6 个月内使用。