MEK/PI3K-IN-2

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MEK/PI3K-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2281803-33-4

MEK/PI3K-IN-2 (compound 6s) 是一种有效的MEK/PI3K抑制剂，其IC₅₀值分别为 352 nM (MEK1), 107 nM (PI3Kα), 和 137 nM (PI3Kδ)。MEK/PI3K-IN-2 抑制 pAKT 和 pERK1/2 水平。MEK/PI3K-IN-2 对肿瘤细胞具有抗增殖活性。

生物活性

MEK/PI3K-IN-2 (compound 6s) is a potentMEK/PI3Kinhibitor, withIC₅₀values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ), respectively. MEK/PI3K-IN-2 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-2 shows anti-proliferative activity against tumor cell lines^[1].

IC₅₀& Target

MEK1

352 ± 2 nM (IC₅₀)

PI3Kα

107 ± 21 nM (IC₅₀)

PI3Kδ

137 ± 7 nM (IC₅₀)

PI3Kγ

2567 ± 364 nM (IC₅₀)

PI3Kβ

3880 ± 725 nM (IC₅₀)

分子量

957.68

Formula

C₃₈H₄₁F₅IN₉O₇

CAS 号

2281803-33-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.