ATI-2341 is a potent and functionally selective allosteric agonist of C-X-Cchemokine receptortype 4(CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs)^[1][2].

ATI-2341 induces CXCR4- and G protein-dependent signaling, receptor internalization, and chemotaxis in CXCR4-expressing cells. ATI-2341 has an EC₅₀value of 194 ± 16 nM and an intrinsic activity of 81 ± 4% in CCRF-CEM cells^[2].

2256.82

C₁₀₄H₁₇₈N₂₆O₂₅S₂

1337878-62-2

1-Oxohexadecyl-MGYQKKLRSMTDKYRL

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.