CB1R Allosteric modulator 4 is a positive allosteric modulator ofcannabinoid type-1(CB1R) with good biological activity. CB1R Allosteric modulator 4 inhibits cAMP production and shows robust activity in β-arrestin-2 recruitment^[1].

CB1R is the most abundant G-protein coupled receptors (GPCR) in the CNS, CB1R involves in regulating physiological processes, from neurotransmission to energy metabolism^[1].
CB1R Allosteric modulator 4 (compound 66b) (0.10 nM-10μM; 30 min) exerts inhibition of forskolin-stimulated cellular cAMP production in CHO hCB1R with an EC₅₀value of 0.05 μM^[1].
CB1R Allosteric modulator 4 (0.10 nM-10μM; 90 min) acts function for β-arrestin-2 recruitment in hCB1R-CHO-K1 cells with an EC₅₀value of 0.163 μM^[1].
CB1R Allosteric modulator 4 (1.6-200 μM; 2 h) improves aqueous solubility with good biological activity, and shows kinetic water solubility with solubility limit of 3.13 μM^[1].

363.43

C₂₀H₁₇N₃O₂S

2633686-53-8

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Please store the product under the recommended conditions in the Certificate of Analysis.