Synaptamide

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Synaptamide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

162758-94-3

包装与价格：

包装	价格(元)
5mg (67 mM * 200 μL in Ethanol)	询价
10mg (67 mM * 400 μL in Ethanol)	询价

Dehydroepiandrosteron(DHEA)
Docosahexaenoyl Ethanolamide

Synaptamide (Dehydroepiandrosteron; DHEA) 是一种内源性代谢物，是 Anandamide 的结构类似物。Synaptamide 与大麻素-1 和 2 (CB1 和 CB2) 大麻素受体结合并具有抗炎特性。Synaptamide 第一个粘附 G 蛋白偶联受体 (aGPCR) 的小分子内源性配体。

生物活性

Synaptamide (Dehydroepiandrosteron; DHEA) is anendogenous metaboliteand structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR)^[1]^[2]^[3].

体外研究
(In Vitro)

Synaptamide (Dehydroepiandrosteron; DHEA) is a weak agonist at both CB1 and CB2 receptors^[2].

体内研究
(In Vivo)

Synaptamide (10 mg/kg; subcutaneously; daily for 7 days) promotes cognitive recovery in rats subjected to mild traumatic brain injury (mTBI)^[1].
Synaptamide (2-10 mg/kg; adult male C57BL/6J mice) reduced the levels of nociceptive and inflammatory pain-related behaviour over 60 min in the intraplantar formaldehyde assay via both intraperitoneal and local intraplantar administration^[2].

Animal Model:	Male Wistar rats;260 ± 20 g, age 3 months; mTBI model)^[1]
Dosage:	10 mg/kg
Administration:	Subcutaneously; daily for 7 days
Result:	Reversed the mTBI-induced cognitive deficits.

分子量

371.56

性状

Liquid

Formula

C₂₄H₃₇NO₂

CAS 号

162758-94-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

溶解性数据

In Vitro:

Ethanol : 25 mg/mL(67.28 mM;Need ultrasonic)