HDAC6/HSP90-IN-1

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HDAC6/HSP90-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2411955-43-4

HDAC6/HSP90-IN-1 (化合物17) 是一种有效的选择性的HDAC6和HSP90的双重抑制剂，IC₅₀值分别为 4.3 和 46.8 nM。HDAC6/HSP90-IN-1 可下调 INF-γ 处理的 H1975 肺癌细胞中 PD-L1 的表达。HDAC6/HSP90-IN-1 在 H1975 异种移植小鼠中抑制肿瘤生长。

生物活性

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor ofHDAC6andHSP90, withIC₅₀values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulatesPD-L1expression in INF-γ treated H1975 lungcancercells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice^[1].

IC₅₀& Target

HDAC6

4.32 nM (IC₅₀)

HSP90

46.8 nM (IC₅₀)

HDAC3

1312 nM (IC₅₀)

HDAC1

1878 nM (IC₅₀)

HDAC8

3720 nM (IC₅₀)

分子量

511.61

Formula

C₂₈H₃₇N₃O₆

CAS 号

2411955-43-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.