PDE5/HDAC-IN-1

立即咨询

PDE5/HDAC-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2414921-48-3

PDE5/HDAC-IN-1 (Compound 26) 是一种有效的磷酸二酯酶 5 （PDE5）和HDAC抑制剂，IC₅₀分别为 46.3 nM 和 14.5 nM。PDE5/HDAC-IN-1 诱导细胞凋亡（apoptosis），具有抗癌活性。

生物活性

PDE5/HDAC-IN-1 (Compound 26) is a potentphosphodiesterase5 (PDE5)andHDACinhibitor withIC₅₀values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cellapoptosisand shows anticancer activities^[1].

IC₅₀& Target

PDE5

46.3 nM (IC₅₀)

HDAC1

2.45 μM (IC₅₀)

HDAC6

0.11 μM (IC₅₀)

HDAC8

0.12 μM (IC₅₀)

体外研究
(In Vitro)

PDE5/HDAC-IN-1 (Compound 26) shows growth inhibition with IC₅₀values of 12.35, 7.19 and 11.79 μM against HT-29, HCT-116 and SW-620 cells, respectively^[1].
PDE5/HDAC-IN-1 shows cytotoxic activity with IC₅₀values of 1.9, 1.5, 2.5, 5.5, 9.8, 18.6, 2 and 28.2 μM against Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D and CCD966SK, respectively^[1].

分子量

553.45

Formula

C₂₇H₂₉BrN₄O₄

CAS 号

2414921-48-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.