ATR-IN-15 (化合物 1) 是一种口服有效的ATR激酶抑制剂，其IC50值为 8 nM。ATR-IN-15 还抑制人结肠癌肿瘤细胞 LoVo、DNA-PK和PI3K，IC50值分别为 47、663 和 5131 nM。
| 生物活性 | ATR-IN-15 (compound 1) is an orally active and potentATRkinase inhibitor, with anIC50of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo,DNA-PKandPI3K, withIC50values of 47, 663 and 5131 nM, respectively[1]. |
| IC50& Target | ATR 8 nM (IC50) | PI3K 5131 nM (IC50) | ATM > 10000 nM (IC50) |
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
