Bis-PEG2-PFP Ester

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Bis-PEG2-PFP Ester

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1314378-18-1

NH2-PEG3-BOC 是一种不可降解 (non-cleavable) 的含 2 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Bis-PEG2-PFP ester 也是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

生物活性

Bis-PEG2-PFP ester is also anon-cleavable2 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1]. Bis-PEG2-PFP ester is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[2].

IC₅₀& Target

PEGs

Alkyl/ether

Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

分子量

538.29

Formula

C₂₀H₁₂F₁₀O₆

CAS 号

1314378-18-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.