Top1 inhibitor 1 (compound 28) is a potent humantopoisomeraseI (Top1)inhibitor with anIC₅₀value of 29 nM^[1].

Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC₅₀: 2.74 μM), HeLa (IC₅₀: 2.61 μM), HCT116 (IC₅₀: 2.34 μM), NIH: OVCAR-3 (IC₅₀: 2.35 μM) cells compared to the non-cancerous cells like HEK293 (IC₅₀: 8.34 μM)^[1].

426.47

C₂₄H₂₂N₆O₂

2302772-05-8

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