Chitin synthase inhibitor 1 is a potent and selectivechitin synthase (CHS)inhibitor (IC₅₀=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants^[1].

IC₅₀: 0.12 mM (CHS)^[1]

Chitin synthase inhibitor 1 (compound 5a) shows broad-spectrum antifungal activity (MIC=4 μg/mL inCandidaalbicans (C. albicans)ATCC 76615 andAspergillus fumigatus (A. fumigatus)GIMCC 3.19; MIC=8 μg/mL inAspergillus flavus (A. flavus)ATCC 16870 andCrytococcusneoformans (C. neoformans)ATCC 32719)^[1].
Chitin synthase inhibitor 1 shows antifungal activity against drug-resistant fungi variants (MIC=32 μg/mL in FluconazoleresistantC.albicansATCC 76615R, Fluconazole-resistantA.fumigatusGIMCC 3.19R, and Fluconazole-resistantC. neoformansATCC 32719R, MicafunginresistantC.albicansATCC 76615R’; MIC=16 μg/mL in Fluconazole-resistantA.flavusATCC 16870R)^[1].

409.87

C₂₂H₂₀ClN₃O₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.