XEN723

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XEN723

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1072803-08-7

XEN723 是一种新型且有效的硬脂酰辅酶 A 去饱和酶 (SCD1) 的噻唑基咪唑烷酮抑制剂，在小鼠和 HepG2 细胞中的IC₅₀值分别为 45 和 524 nM。

生物活性

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor ofStearoyl-CoA Desaturase(SCD1) withIC₅₀s of 45 and 524 nM in mouse and HepG2 cell, respectively.

IC₅₀& Target

IC50: 45 nM (SCD1 in Mouse), 524 nM (SCD1 in HepG2 cell)^[1]

体外研究
(In Vitro)

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC₅₀s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1in vitropotency of more than 560-fold compare to the original high throughput screen (HTS) hit^[1].

分子量

425.48

性状

Solid

Formula

C₂₁H₂₀FN₅O₂S

CAS 号

1072803-08-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(235.03 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3503 mL	11.7514 mL	23.5029 mL
5 mM	0.4701 mL	2.3503 mL	4.7006 mL
10 mM	0.2350 mL	1.1751 mL	2.3503 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。