TRPC6-IN-3

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TRPC6-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2311863-36-0

TRPC6-IN-3 (compound 17) 是一种口服有效的瞬时受体电位 C6 离子通道 (TRPC6) 抑制剂。TRPC6-IN-3 不仅可以调节细胞内钙浓度，还可以通过调节包括钙离子和钠离子在内的阳离子通量来调节膜电位。TRPC6-IN-3 可用于呼吸系统的研究。

生物活性

TRPC6-IN-3 (compound 17) is a potent, orally activetransient receptor potential C6 ion channel (TRPC6)inhibitor. TRPC6-IN-3 modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. TRPC6-IN-3 can be used in research of respiratory system^[1].

体内研究
(In Vivo)

TRPC6-IN-3 (compound 17; 1-10 mg/kg; p.o.; orally 12 h and 2 h before LPS challenge; LPS-induced mice) inhibits LPS-induced vascular leakage and inhibits accumulation of Broncho-Alveolar-Lavage protein (BALF protein) in a mouse model^[1].
TRPC6-IN-3 (3 mg/kg; p.o.; daily, for 4 d; H1N1-induced mice) reduces H1N1-induced vascular leakage in a mouse model^[1].

Animal Model:	LPS-induced mice^[1]
Dosage:	1, 3, and 10 mg/kg
Administration:	Oral administration; orally 12 h and 2 h before LPS challenge
Result:	Reduced BALF protein concentration of 56 % at 3 mg/kg and 62 % at 10 mg/kg.

Animal Model:	H1N1-induced mice^[1]
Dosage:	3 mg/kg
Administration:	Oral administration; daily, for 4 days
Result:	Inhibited Evans blue extravasation from the blood to the BALF and reduced BALF Evans blue by 24 % at 3 mg/kg.

分子量

423.44

Formula

C₂₂H₂₂FN₅O₃

CAS 号

2311863-36-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.