Polygalacturonic acid

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

25990-10-7

Galacturonic acid polymer

Polygalacturonic acid (Galacturonic acid polymer) 是透明胶状酸，是细胞壁的主要成分。Polygalacturonic acid 可用于制备银纳米颗粒 (AgNPs)，作为抗氧化剂和抗炎剂，保护细胞免受 ROS 升高的破坏作用，并加速伤口愈合。Polygalacturonic acid 纳米颗粒也表现出抗菌活性。

生物活性

Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity^[1]^[2].

体外研究
(In Vitro)

Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugatedIbuprofen(HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect ofIbuprofen^[1].
Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts^[1].
Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains;Bacillus SubtilisandStaphylococcus Aureus, as well as gram-negative bacterial strain;Escherichia Coli^[2].

体内研究
(In Vivo)

Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats^[2].

Animal Model:	Full thickness wound model in albino rats (60-day-old, 180 g)^[2]
Dosage:	Ag-Polygalacturonic acid/hyaluronic acid nanoparticles
Administration:	Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days
Result:	Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively. Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.

Formula

(C₆H₁₀O₇)x

CAS 号

25990-10-7

中文名称

聚半乳糖醛酸；半乳糖醛酸聚合物

结构分类

Saccharides
Polysaccharides

Others

来源

Plants
Rosaceae
Malus pumilaMill.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.