KAAD-Cyclopamine 是 hedgehog 信号通路的抑制剂，是smoothened的拮抗剂。
| 生物活性 | KAAD-Cyclopamine, ahedgehogsignaling inhibitor, is asmoothenedantagonist[1]. |
体外研究
(In Vitro) | KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC50of 3 nM, wheras this cyclopamine derivative has an IC50of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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