YO-01027 (Dibenzazepine) (GMP) isYO-01027(HY-13526) produced by using GMP guidelines.GMP small moleculeswork appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potentγ-secretaseinhibitor^[1][2].

IC50: 2.92±0.22 (Notch), 2.64±0.30 (APPL) nM^[1]

YO-01027 (0.25-10 μM, during 1-18 days) promotes iPSC generation from human neonatal keratinocytes^[2].
YO-01027 (2 μM, 3 days) does not affect p53 activity in OCT4, SOX2-transduced human keratinocytes^[2].
YO-01027 (10 μM, 3 days) promotes the proliferation of supporting cells (SCs) in cultured mouse cochleae^[3].
YO-01027 (10 μM, 3 days) generates new hair cell (HCs) and increases the HCs number in neonatal mouse cochleae^[3].

463.48

C₂₆H₂₃F₂N₃O₃

209984-56-5

二苯并氮卓 (GMP)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.