Norfluoxetine (hydrochloride) 是氟西汀的活性 N-去甲基化代谢物。
| Cas No. | 57226-68-3 |
| 别名 | 去甲氟西汀,Desmethylfluoxetine |
| 化学名 | γ-[4-(trifluoromethyl)phenoxy]-benzenepropanamine, monohydrochloride |
| Canonical SMILES | NCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.Cl |
| 分子式 | C16H16F3NO•HCl |
| 分子量 | 331.8 |
| 溶解度 | 30mg/mL in ethanol, 30mg/mL in DMSO, 30mg/mL in DMF |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35 [1] . The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).[1][2] Reference:
[1]. Wong, D.T., Bymaster, F.P., Reid, L.R., et al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology 8(4), 337-344 (1993).
[2]. Hiemke, C., and Hartter, S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacology & Therapeutics 85(1), 11-28 (2000). |
