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UNC 926 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
UNC 926 hydrochloride图片
CAS NO:1184136-10-4
包装与价格：
包装价格(元)
10mg询价
50mg询价

UNC 926 hydrochloride 是一种甲基赖氨酸 (Kme) 阅读器结构域抑制剂，可抑制 L3MBTL1，IC50 为 3.9 μM.
Cas No.1184136-10-4
化学名(3-bromophenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone hydrochloride
Canonical SMILESO=C(C1=CC=CC(Br)=C1)N2CCC(N3CCCC3)CC2.Cl
分子式C16H21BrN2O.HCl
分子量373.72
溶解度Soluble in DMSO
储存条件Desiccate at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM.

UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. L3MBTL1UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1[1].

References:
[1]. Herold JM, et al. Structure–activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45–51.

 
 
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