Naspm(1-Naphthylacetyl spermine)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

122306-11-0

包装与价格：

Naspm (1-Naphthylacetyl semimine) (1-Naphthyl acetyl semimine) 是 Joro 蜘蛛毒素的合成类似物，是一种钙渗透性 AMPA (CP-AMPA) 受体拮抗剂。

Cas No.	122306-11-0
别名	1-Naphthylacetyl spermine
Canonical SMILES	O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1
分子式	C₂₂H₃₄N₄O
分子量	370.53
溶解度	DMSO : 10 mg/mL (26.99 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1]. [1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.