Dauricine 是存在于 Asiatic Moonseed Rhizome 中的一种双苯异喹啉生物碱，具有抗炎活性。Dauricine 通过抑制 NF-κB 激活，抑制结肠癌细胞的增值、侵袭，并诱导凋亡，且具有剂量依赖性。
| Cas No. | 524-17-4 |
| 别名 | 蝙蝠葛碱 |
| Canonical SMILES | OC1=CC=C(C[C@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4 |
| 分子式 | C38H44N2O6 |
| 分子量 | 624.77 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer[1]. [1]. Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75. |
