GX-936 (GX936; PF-05196233; PF 05196233) is a novel and potent Nav1.7 inhibitor with the potential to be used to treat cardiovascular and neurological disorders. It acts by binding to the activated state of voltage-sensor domain IV (VSD4), and shows robust inhibition of the 1KαPMTX-evoked N1742K response (IC50 =40 nM). Voltage-gated sodium (Nav) channels propagate action potentials in excitable cells. Accordingly, Nav channels are therapeutic targets for many cardiovascular and neurological disorders.

纯度：≥98%

CAS：1235406-09-3