基因名：
As3mt
产品别名：
2310045H08Rik； Cyt19； As3mt； arsenite methyltransferase； arsenite methyltransferase； arsenite methyltransferase； S-adenosyl-L-methionine:arsenic(III) methyltransferase； S-adenosylmethionine:arsenic (III) methyltransferase； arsenic (+3 oxidation state) methyltransferase； methylarsonite methyltransferase； methyltransferase Cyt19； 甲基转移酶cyt-19；
背景信息：
Formation of methylated metabolites is a critical step in the metabolism of inorganic arsenic. Arsenite methyltransferase (cyt19) is localized to the cytoplasm and operates in the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate which is reduced to methylarsonite. Methylarsonite acts as a substrate and is converted into a much less toxic compound dimethylarsinate. cyt19 is highly expressed in liver. Inherited variation in cyt19 may contribute to variation in arsenic metabolism and possibly arsenic-dependent carcinogenesis in humans.
