基因名：
Fbxw7
产品别名：
1110001A17Rik； AGO； Cdc4； Fbw7； Fbwd6； Fbx30； Fbxo30； Fbxw6； SEL-10； Fbxw7； F-box and WD-40 domain protein 7； F-box and WD-40 domain protein 7； F-box/WD repeat-containing protein 7； F-box and WD-40 domain protein 7, archipelago homolog； F-box and WD-40 domain-containing protein 7； F-box-WD40 repeat protein 6； f-box only protein 30； Fbxw7蛋白； 含F-框WD重复域蛋白7(FBXW7)；
背景信息：
The F-box protein family is characterized by an approximately 40 amino acid motif known as the F-box. F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. One family member, Cdc4, also known as AGO, FBW7, FBXW7, FBX30, SEL10, and FLJ11071, maps to human chromosome 4q31.3. Alternative splicing of this gene generates four transcript variants. In addition to an F-box, Cdc4 contains seven tandem WD40 repeats. Cdc4 binds directly to cyclin E and targets cyclin E for ubiquitin-mediated degradation. Mutations of the Cdc4 gene are detected in ovarian and breast cancer cell lines, suggesting that the gene may be involved in the pathogenesis of human cancers.
