基因名：
ATG5
产品别名：
APG5； APG5-LIKE； APG5L； ASP； SCAR25； hAPG5； ATG5； autophagy related 5； autophagy related 5； autophagy protein 5； APG5 autophagy 5-like； ATG5 autophagy related 5 homolog； apoptosis-specific protein； 自噬相关蛋白5(ATG5)； 自噬蛋白5/细胞凋亡的特异性蛋白；
背景信息：
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an important role in the apoptotic process, possibly within the modified cytoskeleton.
