基因名：
SKAP1
产品别名：
HEL-S-81p； SCAP1； SKAP55； SKAP1； src kinase associated phosphoprotein 1； src kinase associated phosphoprotein 1； src kinase-associated phosphoprotein 1； SKAP-55； epididymis secretory sperm binding protein Li 81p； pp55； src family-associated phosphoprotein 1； src kinase-associated phosphoprotein of 55 kDa； SKAP55蛋白； Src激酶关联磷蛋白1(SKAP1)；
背景信息：
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines. SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
