基因名：
PFKFB4
产品别名：
PFKFB4； 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4； 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4； 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4； 6PF-2-K/Fru-2,6-P2ase 4； 6PF-2-K/Fru-2,6-P2ase testis-type isozyme； PFK/FBPase 4； bifunctional enzyme with kinase and biphosphatase activities； 果糖-2,6-二磷酸酶4；
背景信息：
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
