基因名：
SMAD3
产品别名：
HSPC193； HsT17436； JV15-2； LDS1C； LDS3； MADH3； hMAD-3； hSMAD3； mad3； SMAD3； SMAD family member 3； SMAD family member 3； mothers against decapentaplegic homolog 3； MAD homolog 3； MAD, mothers against decapentaplegic homolog 3； SMA- and MAD-related protein 3； SMAD, mothers against DPP homolog 3； mad homolog JV15-2； mad protein homolog； mothers against DPP homolog 3； Smad同源物3(SMAD3)； 磷酸化细胞信号转导分子SMAD3； 细胞信号转导分子SMAD3；
背景信息：
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. It also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. SMAD3 has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive.
