基因名：
DNAJA1
产品别名：
DJ-2； DjA1； HDJ2； HSDJ； HSJ-2； HSJ2； HSPF4； NEDD7； hDJ-2； DNAJA1； DnaJ heat shock protein family (Hsp40) member A1； DnaJ heat shock protein family (Hsp40) member A1； dnaJ homolog subfamily A member 1； DnaJ (Hsp40) homolog, subfamily A, member 1； dnaJ protein homolog 2； heat shock 40 kDa protein 4； heat shock protein J2； heat shock protein, DNAJ-like 2； human DnaJ protein 2； neural precursor cell expressed, developmentally down-regulated 7； 40kDa热休克蛋白4(HSPF4)； 热休克蛋白相关蛋白4；
背景信息：
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
