The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. T2-cadherin, also known as cadherin-10 or CDH10, is a 788 amino acid single-pass type I membrane protein that belongs to the cadherin family and contains five cadherin domains. Expressed predominately in brain, but also found in prostate and both adult and fetal kidney, T2-cadherin functions as a calcium-dependent cell adhesion protein that is thought to be involved in the maintenance of synaptic adhesions, axon outgrowth and guidance.