基因名:
KLK3
产品别名:
APS; KLK2A1; PSA; hK3; KLK3; kallikrein related peptidase 3; kallikrein related peptidase 3; prostate-specific antigen; P-30 antigen; gamma-seminoprotein; kallikrein-3; semenogelase; seminin; 前列腺特异性抗原(天然蛋白); 激肽释放酶3/舒血管素3;
背景信息:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen members of the Kallikrein subfamily located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.