靶标：
TMPRSS2
产品别名：
PRSS10； TMPRSS2； transmembrane serine protease 2； transmembrane serine protease 2； transmembrane protease serine 2； epitheliasin； serine protease 10； transmembrane protease, serine 2； 丝氨酸蛋白酶10； 跨膜丝氨酸蛋白酶2(TMPRSS2)；
背景信息：
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],
