靶标：
GFRA1
产品别名：
GDNFR； GDNFR-alpha-1； GDNFRA； GFR-ALPHA-1； GFRalpha-1； RET1L； RETL1； RHDA4； TRNR1； GFRA1； GDNF family receptor alpha 1； GDNF family receptor alpha 1； GDNF family receptor alpha-1； GDNF receptor alpha 1d； GDNF receptor alpha 1e； GPI-linked anchor protein； Glial cell line-derived neurotrophic factor receptor alpha； PI-linked cell-surface accessory protein； RET ligand 1； TGF-beta-related neurotrophic factor receptor 1； GDNF家族受体α-1； 胶质细胞系来源神经营养因子受体α1(GFRa1)；
背景信息：
This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],
