A major metabolite of olanzapine
货号:ajcx24640
CAS:161696-76-0
分子式:C16H18N4S
分子量：298.4
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-desmethyl Olanzapine is a major metabolite of the atypical antipsychotic agent olanzapine .^1,2N-desmethyl Olanzapine is formedviaoxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoform CYP1A2.¹

1.Ring, B.J., Catlow, J., Lindsay, T.J., et al.Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapineJ. Pharmacol. Exp. Ther.276(2)658-666(1996) 2.Chiu, J.A., and Franklin, R.B.Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detectionJ. Pharm. Biomed. Anal.14(5)609-615(1996)