DMA-135 hydrochloride 抑制肠道病毒 71 型 (EV71) IRES依赖的翻译和复制。DMA-135 hydrochloride 以中等高亲和力(KD=?520? nM) 结合 EV71 的 SLII 结构域。DMA-135 hydrochloride 在基于细胞的研究中没有显著毒性。
货号:ajcx37998
CAS:2237925-62-9
分子式:C16H18ClN7O
分子量：359.81
溶解度:DMSO : 50 mg/mL (138.96 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1].

[1]. Davila-Calderon J, Patwardhan NN, Chiu LY, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22.