ARX-1796 (AV-006) 是一种 Avibactam 前药，是口服生物利用的 β-内酰胺酶 (β-lactamase) 抑制剂。Avibactam 具有对 A 类和 C 类β-内酰胺酶的抑制谱，包括 ESBLs、AmpC 和肺炎克雷伯菌碳青霉烯酶 (KPC) 酶。
货号:ajcx35806
CAS:2245880-46-8
分子式:C14H23N3O8S
分子量：393.41
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ARX-1796 (AV-006), an Avibactam prodrug, is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes[1][2].

[1]. Veeraraghavan B, et al. Oral Antibiotics in Clinical Development for Community-Acquired Urinary Tract Infections. Infect Dis Ther. 2021;10(4):1815-1835. [2]. Falcone M, et al. Spotlight on ceftazidime/avibactam: a new option for MDR Gram-negative infections. J Antimicrob Chemother. 2016;71(10):2713-2722.