BTSA1 是一种有效的，高亲和力和口服活性的 BAX 激活剂，IC50 为 250 nM，EC50 为 144 nM。BTSA1 以高亲和力和特异性与 N 末端激活位点结合，并诱导 BAX 发生构象变化，从而导致 BAX 介导的细胞凋亡。
货号:ajcx16472
CAS:314761-14-3
分子式:C21H14N6OS2
分子量：430.51
溶解度:DMSO: 25 mg/mL (58.07 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].

[1]. Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10.