Endogenous ligand of the APJ receptor
货号:ajcx21686
CAS:N/A
分子式:C69H111N23O16S.XCF3COOH
分子量：1550.8
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC₅₀value of 0.37 nM (the EC₅₀values for apelin-17 and apelin-36 are 2.5 and 20 nM, respectively).^1,2It acts primarily in the periphery and central nervous system, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity.³Unlike apelin-36, apelin-13 poorly blocks the entry of human immunodeficiency virus into cells.⁴

1.Tatemoto, K., Hosoya, M., Habata, Y., et al.Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptorBiochemical and Biophysical Research Communications251471-476(1998) 2.Lee, D.K., Cheng, R., Nguyen, T., et al.Characterization of apelin, the ligand for the APJ receptorJournal of Neurochemistry7434-41(2000) 3.Kleinz, M.J., and Davenport, A.P.Emerging roles or apelin in biology and medicinePharmacology & Therapeutics107198-211(2005) 4.Zou, M.X., Liu, H.Y., Haraguchi, Y., et al.Apelin peptides block the entry of human immunodeficiency virus (HIV)FEBS Letters47315-18(2000)