Phenyltoloxamine

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Phenyltoloxamine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

92-12-6

Bistrimin
Histionex

Phenyltoloxamine (Bistrimin) 是一种具有镇静和镇痛作用的抗组胺剂。Phenyltoloxamine 还具有有效的Sigma-1 受体结合亲和力 (K_i: 160 nM)。

生物活性

Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potentSigma-1 receptorbinding affinity (K_i: 160 nM)^[1]^[2]^[3].

IC₅₀& Target^[3]

Sigma 1 Receptor

160 nM (Ki)

体外研究
(In Vitro)

Phenyltoloxamine (10-50 μM, 24 h) demonstrates cytotoxicity in EVSA-T cells^[2].
Phenyltoloxamine exhibits potent Sigma 1 Receptor (S1R) binding affinity with a K_ivalue of 160 nM^[3].
Phenyltoloxamine (100 μM) inhibits human liver macrosaml CYP2D6 enzyme by 99.0%^[4].

分子量

255.35

Formula

C₁₇H₂₁NO

CAS 号

92-12-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.