MAO-B-IN-5

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MAO-B-IN-5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

849909-77-9

MAO-B-IN-5 是一种有效的、选择性和具有口服活性的MAO-B抑制剂，IC₅₀值为 0.204 μM。MAO-B-IN-5 具有研究帕金森病 (PD) 的潜力。

生物活性

MAO-B-IN-5 is a potent, selective and orally activeMAO-Binhibitor with anIC₅₀of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)^[1].

IC₅₀& Target

MAO-B

34.190 μM (IC₅₀)

MAO-A

0.204 μM (IC₅₀)

体外研究
(In Vitro)

MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with theIC₅₀s of 34.190 μM and 0.204 μM for MAO-A and MAO-B, respectively^[1].

体内研究
(In Vivo)

MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%)^[1].
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats^[1].

Compound	Route	Dose (mg/kg)	C_max(ng/mL)	AUC_t(ng·h/mL)	T_1/2(h)	Vss (h)	Cl (mL/min/kg)	F (%)
D0	iv	1	809	347	0.37	1.11	47.1	/
	po	5	163	284	1.27	/	/	16.3

SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o.^[1].

Animal Model:	SD rats^[1]
Dosage:	1, 5 mg/kg
Administration:	1 mg/kg, i.v.; 5 mg/kg, p.o.
Result:	Showed oral bioavailability in rats (F=16.3%).

分子量

328.38

Formula

C₁₉H₂₁FN₂O₂

CAS 号

849909-77-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.