Ciprofibrate (Win35833) 是一种有效的过氧化物酶体增殖剂，可增加 PPARalpha 的磷酸化水平。
| Cas No. | 52214-84-3 |
| 别名 | 环丙贝特; Win35833 |
| 化学名 | 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid |
| Canonical SMILES | CC(C(O)=O)(OC1=CC=C(C2CC2(Cl)Cl)C=C1)C |
| 分子式 | C13H14Cl2O3 |
| 分子量 | 289.15 |
| 溶解度 | ≥ 10.85 mg/mL in DMSO, ≥ 94.6 mg/mL in EtOH |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ciprofibrate is a peroxisome proliferator-activated receptor agonist.Target: PPARCiprofibrate is a hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. Known to be a PPARα (peroxisome proliferator-activated receptor α) agonist [1, 2]. References:
[1]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8.
[2]. Clemencet, M.C., et al., Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate. Cancer Lett, 2005. 222(2): p. 217-26. |
