4-Vinylphenol is found in the medicinal herbHedyotis diffusaWilld, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol inducesapoptosisand inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo^[1].

4-Vinylphenol (12.5-200 μg/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 μg/mL^[1].
4-Vinylphenol (0.15 or 0.3 μg/mL; 3 days) reduces sphere-formation and vimentin expression on CSCs in breast cancer^[1].
4-Vinylphenol (50, 100 μg/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells^[1].
4-Vinylphenol (100 μg/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis^[1].

120.15

Liquid

C₈H₈O

2628-17-3

4-乙烯基苯酚

• Phenols
• Monophenols

• Plants
• Rubiaceae
• Hedyotis diffusaWilld.

recombinant Streptomyces mobaraense

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years