Istaroxime (PST2744) is a potent inhibitor ofNa⁺,K⁺-ATPasewithIC₅₀of 0.11 μM.

IC50: 0.11 μM (Na⁺,K⁺-ATPase)^[1]

Istaroxime acting as a positive inotropic compound through the inhibition of the Na⁺,K⁺-ATPase^[2]. Istaroxime (PST2744) inhibits the Na⁺/K⁺-ATPase activity from dog kidney with an IC₅₀value of 0.43 ± 0.15 μM. Inhibition of Na⁺/K⁺-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744^[3].

Istaroxime (PST2744) induces a progressive increase in +dP/dt_maxthroughout the infusion that reaches 80% (ED₈₀) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (ED_max) of 4.88±0.6 mg/kg^[3].

360.49

C₂₁H₃₂N₂O₃

203737-93-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.