UC-1V150

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UC-1V150

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

927822-45-5

UC-1V150 是一种特异性TLR7激活剂，可刺激细胞免疫反应，具有抗肿瘤活性。UC-1V150 可以用于合成 ISAC 分子。

生物活性

UC-1V150 is a specificTLR7(Toll-like receptor) agonist that stimulates cellular immune responses and has anti-tumor activity. UC-1V150 can be used to synthesize ISAC (Immune-Stimulating Antibody Conjugates) molecule^[1]^[2].

IC₅₀& Target

TLR7

体外研究
(In Vitro)

UC-1V150 (0.01-10 μM, 24 hour) can stimulate the release of IL-6 and IL-2 cytokines effectively in bone-marrow-derived macrophages^[1].
UC-1V150 (1 μg/mL, 48 hours) can increase the expression of FcγRIIA and FcγRIII while inducing an approximately 1.5-fold increase in macrophage phagocytosis index of target cells in hman monocyte-derived macrophages (hMDM)^[2].

体内研究
(In Vivo)

UC-1V150 (intravenous injection, 0.38-38 nM, once) effectively induces release of serum cytokines within a certain concentration range in female C57BL/6 mice (5-6 weeks of age)^[1].

Animal Model:	Female C57BL/6 mice (5-6 weeks of age)^[1]
Dosage:	0.38-38 nM
Administration:	Intravenous injection; once
Result:	Induced serum cytokine IL-6 levels about 0.1 ng/mL and IL-2 levels about 1.5 ng/mL at the concentration of 38 nM.

分子量

343.34

Formula

C₁₆H₁₇N₅O₄

CAS 号

927822-45-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.