D18 是一种免疫调节剂。D18 作为TLR7/8双激动剂发挥作用 (对于 hTLR7，EC50=24nM，对于 hTLR8，EC50=10nM)。D18 通过表观遗传调节增加 PD-L1 表达，从而使肿瘤对 PD-1/PD-L1 阻断敏感。D18 是一种 ADC 细胞毒剂，用于合成 ADC HE-S2。
| 生物活性 | D18 is an immune modulator. D18 acts as aTLR7/8dual agonist (EC50=24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increasesPD-L1expression through epigenetic regulation, thus sensitizing tumors toPD-1/PD-L1blockade. D18 is aADC cytotoxinuesd for the systhesis of ADC HE-S2[1]. |
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
