Saccharopine

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Saccharopine

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CAS NO:

997-68-2

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

L-酵母氨酸
L-Saccharopine

Saccharopine (L-Saccharopine) 是赖氨酸的降解中间体，是一种线粒体毒素。赖氨酸-酮戊二酸还原酶将赖氨酸和 α-酮戊二酸转化为 Saccharopine。糖精脱氢酶将 Saccharopine 氧化为 α-氨基己酸酯半醛和谷氨酸。Saccharopine 通过破坏线粒体稳态而损害发育。

生物活性

Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis^[1]^[2]^[3].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 inC. elegans^[1].

体内研究
(In Vivo)

Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation inAassmutant mice^[1].

分子量

276.29

Formula

C₁₁H₂₀N₂O₆

CAS 号

997-68-2

中文名称

L-酵母氨酸；酵母氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.