GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site^[1].

GAP (10 nM; 4 h) stimulates the release of both gonadotropins in anterior pituitaries from female Sprague-Dawley rats, but inhibits the basal secretion of prolactin by ~50%, compared with inhibition levels reported for dopamin, a known prolactin-inhibiting factor^[2].
GAP (0.1-10 nM; 3-4 h) inhibits prolactin secretion by 40-45%, with an IC₅₀value of 0.25 nM^[2].

3285.60

C₁₄₀H₂₂₆N₄₀O₄₉S

106061-19-2

FECTTHQPRSPLRDLKGALESLIEEETGQ

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.