YS121 是一种微粒体前列腺素 E2 合酶-1 (mPGES-1;IC50=3.4 μM) 和 5-脂氧合酶 (5-LOX;IC50=6.5 μM) 的双重抑制剂。在 IL-1β 刺激的 A549 细胞中，YS121剂量依赖性地减少 PGE2 的产生，EC50为 12 μM。
| 生物活性 | YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1;IC50=3.4 μM) and 5-lipoxygenase (5-LOX;IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
