PROTAC BRD4 Degrader-2 是由Cereblon配体和BRD4配体相连的PROTAC，对BRD4 BD1的IC50为 14.2 nM。
| 生物活性 | PROTACBRD4 Degrader-2 is aPROTACconnected by ligands forCereblonandBRD4with anIC50of 14.2 nM againstBRD4BD1[1]. |
| IC50& Target[1] | BRD4 BD1 14.2 nM (IC50) | Cereblon |
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体外研究
(In Vitro) | PROTAC BRD4 Degrader-2 (Compound 17) inhibits the growth of THP-1 cell line with an IC50of 1.83±0.016 μM[1].
Cell Proliferation Assay[1] | Cell Line: | Human monocyte lymphoma cell line THP-1 | | Concentration: | 72 hours | | Incubation Time: | 0.81-3.26 μM | | Result: | Showd high anti-proliferative potency. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
