ID   DDX41_DICDI             Reviewed;         671 AA.
AC   Q54KG1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable ATP-dependent RNA helicase ddx41;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein 41;
GN   Name=ddx41; ORFNames=DDB_G0287361;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16512674; DOI=10.1021/pr050350q;
RA   Reinders Y., Schulz I., Graef R., Sickmann A.;
RT   "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT   by comparative proteomic approaches.";
RL   J. Proteome Res. 5:589-598(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX41 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000100; EAL63748.1; -; Genomic_DNA.
DR   RefSeq; XP_637262.1; XM_632170.1.
DR   AlphaFoldDB; Q54KG1; -.
DR   SMR; Q54KG1; -.
DR   IntAct; Q54KG1; 1.
DR   STRING; 44689.DDB0233452; -.
DR   PaxDb; Q54KG1; -.
DR   EnsemblProtists; EAL63748; EAL63748; DDB_G0287361.
DR   GeneID; 8626092; -.
DR   KEGG; ddi:DDB_G0287361; -.
DR   dictyBase; DDB_G0287361; ddx41.
DR   eggNOG; KOG0341; Eukaryota.
DR   HOGENOM; CLU_003041_16_5_1; -.
DR   InParanoid; Q54KG1; -.
DR   OMA; DMLDKKM; -.
DR   PhylomeDB; Q54KG1; -.
DR   Reactome; R-DDI-1834941; STING mediated induction of host immune responses.
DR   PRO; PR:Q54KG1; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd17951; DEADc_DDX41; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR044113; DEADc_DDX41.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Coiled coil; Helicase; Hydrolase; Metal-binding;
KW   Nucleotide-binding; Nucleus; Reference proteome; RNA-binding; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..671
FT                   /note="Probable ATP-dependent RNA helicase ddx41"
FT                   /id="PRO_0000328113"
FT   DOMAIN          253..438
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          449..609
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   ZN_FING         635..652
FT                   /note="CCHC-type"
FT   REGION          33..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          19..43
FT                   /evidence="ECO:0000255"
FT   COILED          100..154
FT                   /evidence="ECO:0000255"
FT   MOTIF           222..250
FT                   /note="Q motif"
FT   MOTIF           386..389
FT                   /note="DEAD box"
FT   COMPBIAS        33..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         266..273
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   671 AA;  76076 MW;  48272006BE24E1B9 CRC64;
     MSEESRKHDI EEQHIEKWIP LKERKLNQIK SKLNNLKQQQ PQQHSQQQEN EQNNATATNT
     NITNTTTTTT TTTTTTTSSN NDNNFEDEKK PIYQQSQSLL DQKFEMIKKQ ENKTQRELQQ
     GGTIIENDVN SSNNNNNNGE ENKIKEEKRL DMEESDILKS LKTFKPLVSV KDRAKDVIYT
     DSIKTNWRAP RYILERDEKD HQKVRDQLNI ITDGEDIPPP ITTFKEMKIP KPVIDVLLEK
     GIKKPSPIQV QGLPVILSGR DMIGIAYTGS GKTLVFTLPM VLFALEEECK LPIIQGEGPF
     GLILCPSREL ARQTYDLVNS FTNALHKNGG HPQLRTLLAI GGIDLREQEH IFKKGVHMII
     ATPGRLLDLL NKKKINFKLC KYLGLDEADR LIDLGFEDDI RSVLDNFTNQ RQTLLFSATM
     PKKIQEFARS ALVLPVEVNV GRAGAANLNV TQEVEFVKPE AKIVYLLECL QKTPPPVLIF
     CENKKDVDDI YEYLLLKQVE AVSIHGDKSQ DERESAIKAF REGKKDVLVA TDVASKGLDF
     PEIQHVINFD MPREIENYIH RIGRTGRRGN KGVATTFINK NNTESLLLDL KYLLIEAKQK
     VPPALLEIPD DNQYLQKLQD RNGNTGGGAD DDDTKPCEYC DGRGHRLVNC PKLKKQAGPK
     RDFFGSGGGD W