DDX17_DICDI
ID DDX17_DICDI Reviewed; 785 AA.
AC Q54CE0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Probable ATP-dependent RNA helicase ddx17;
DE EC=3.6.4.13;
DE AltName: Full=DEAD box protein 17;
GN Name=ddx17; ORFNames=DDB_G0293168;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable ATP-dependent RNA helicase which may be involved
CC nonsense-mediated mRNA decay and ribosome biogenesis through rRNA
CC processing. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC family of RNA helicases and controls ATP binding and hydrolysis.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000199; EAL60936.1; -; Genomic_DNA.
DR RefSeq; XP_629279.1; XM_629277.1.
DR AlphaFoldDB; Q54CE0; -.
DR SMR; Q54CE0; -.
DR STRING; 44689.DDB0233431; -.
DR PaxDb; Q54CE0; -.
DR PRIDE; Q54CE0; -.
DR EnsemblProtists; EAL60936; EAL60936; DDB_G0293168.
DR GeneID; 8629001; -.
DR KEGG; ddi:DDB_G0293168; -.
DR dictyBase; DDB_G0293168; ddx17.
DR eggNOG; KOG0331; Eukaryota.
DR HOGENOM; CLU_003041_16_9_1; -.
DR InParanoid; Q54CE0; -.
DR OMA; HLARDIC; -.
DR PhylomeDB; Q54CE0; -.
DR Reactome; R-DDI-3899300; SUMOylation of transcription cofactors.
DR Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:Q54CE0; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; ISS:dictyBase.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Helicase; Hydrolase; Nonsense-mediated mRNA decay;
KW Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW RNA-binding; rRNA processing.
FT CHAIN 1..785
FT /note="Probable ATP-dependent RNA helicase ddx17"
FT /id="PRO_0000327411"
FT DOMAIN 415..590
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 602..763
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 1..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 384..412
FT /note="Q motif"
FT MOTIF 538..541
FT /note="DEAD box"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 428..435
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 785 AA; 84021 MW; 06F1CBB5D4A9A6D4 CRC64;
MSYNSSNSGS GRYDDNRSGN SSYSSTSRGG SSYGNRSGSD RDYNRDGGSY NRDSSRDYNS
SSGSGSGNGS SSYNKYPSSS SSSSSSSSTS SYGPSKGKDF QDSWGSSSTG TTNGYNGSSN
GYNSSSNGYN SSNSSSSYGA SNNGYNNSSG SSSSGSSGSS NGGSYNNSGS SNSNGYSKPT
SNYSYSNGYT GPTTNYSSYS NGYSTPPTST STSSSSTTTT TTTTPSTSYN GGSTSYGYST
SGSSNGYGGY SQPPIPSYDP SSVSSYGAVT PASSSYNASV PGSSYGNSTY RSSGYGNQSY
ATTNSYGSSS YGSSGFYGNA KANTGSFGSA LSPISWDLSK LPRFEKNFYL EHPDVSKFTQ
EEIEKFRASF QMTVKGREVP PPIMQFTQAP FPGYLMKEII GAGFPNPTPI QSQAWPIALK
GRDIIGLAKT GSGKTLAFLL PSIVHINAQP VLREDDGPIV LVLAPTRELA LQIQEETNKF
GGTSQISNTC VYGGASKHTQ VAALKKGVEI VIATPGRLID ILESGKTNLR RVTYLVLDEA
DRMLDMGFEP QIRKIISQIR PDRQTLMFSA TWPKEVQALA HDFLTDHIQV HIGSTEITAN
HNVRQIVEVC QDFEKKERML SFLGSVGRDE KVIVFAETRK GVDDLQRVLQ FSGFKSIGIH
GNKSQPERDF VLSQFKNGMV PIMIATDVAS RGLDIKDIKY VVNYDFPNTI EVYIHRIGRT
ARAGASGVSY SLLTTDNARL ANELIKVLTE AKQKIPIELS NLSVTPSTSS NTKKFSPYPT
YSKRY
